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Updated: 18 Jul 2025

Top 10 Cat Flea And Tick Medications

#1
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TevraPet Actispot II Flea Treatment for Large Cats 9+ lbs | 6 Doses | Powerful Prevention and Control

Brand: TevraPet
$29.97 ($5.00 / Coun
⭐ 4.6
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    POWERFUL FLEA KILLING TREATMENT FOR LARGE CATS: TevraPet Actispot II is a waterproof topical for cats that kills fleas, flea eggs, and flea larvae for up to 30 days after each application
  • VET APPROVED FORMULA: TevraPet Actispot II uses Imidacloprid and Pyriproxyfen - the same safe and effective active ingredients found in Advantage II - but costs far less. Every cat deserves veterinarian quality treatment, Actispot II helps you provide the same level of care without breaking the bank
  • FAST ACTING AND LONG-LASTING WITH NO BITING REQUIRED: TevraPet Actispot II REPELS and KILLS fleas on contact, without your cat being exposed to bites. Begins killing within 24 hours of application, and starts repelling immediately. Other oral flea tablets, pills, and chews require that your pet is bitten by a pest before the meds can start working, potentially exposing your kitty to flea borne diseases
  • BREAK THE CYCLE, PREVENT REINFESTATION: Unlike other flea medications that only temporarily control fleas, Actispot II flea treatment stops infestations dead in their tracks by effectively breaking the flea life cycle. Actispot II safely kills flea eggs and larvae to prevent re-infestation so your cat can get on with napping in the sun and strolling (or stalking!) through the garden
  • EASY-TO-USE, MADE IN AMERICA: We proudly make every dose of Actispot II here in the USA and rigorously test for quality and potency. Each package comes with six (6) easy to apply, fully waterproof topical applications that ensure your friend has safe and reliable flea protection and control for up to six (6) months
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#2
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Amazon Basics Topical Flea Treatment for Medium Cats (5-9 Pounds), 4 Count (Previously Solimo)

Brand: Amazon Basics
$19.94 ($4.98 / Coun
⭐ 4.4
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    Same product, new look – This product is identical in manufacturing and formulation as the Solimo brand
  • One 4 dose pack of Amazon Basics Flea Topical Treatment for Small Cats (5 - 9 pounds), 4 Count (Previously Solimo)
  • Amazon Basics Flea Topical starts eliminating fleas within 12 hours of treatment
  • Active ingredients Imidacloprid and Pyriproxyfen prevent flea infestations by killing flea eggs and flea larvae
  • Packaging received may vary: you may receive product in Solimo or Amazon Basics packaging
  • Amazon Basics Flea Topical does not expire
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#3
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Advantage II Small Cat Vet-Recommended Flea Treatment & Prevention | Cats 5-9 lbs. | 2-Month Supply

Brand: Advantage
No Price
⭐ 5
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    Advantage II Small Cat is a leading brand in cat flea treatment and prevention for small cats 5-9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
  • Fragrance-free formula, waterproof after 24 hours of application
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#4
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PetArmor Plus Flea and Tick Prevention for Cats, Cat Flea and Tick Treatment, 6 Doses, Waterproof Topical, Fast Acting, Cats Over 1.5 lbs

Brand: PetArmor
$39.93 ($6.66 / Coun
⭐ 4.7
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    EFFECTIVE, WATERPROOF FLEA TREATMENT FOR CATS: PetArmor Plus is a waterproof, flea & tick topical prevention for cats that kills fleas, flea eggs, flea larvae, ticks, and chewing lice for up to 30 days after application.
  • TRUSTED, VET QUALITY FORMULA: Containing fipronil and (S)-methoprene, the same active ingredients as FRONTLINE Plus for Cats. PetArmor Plus for Cats has a powerful formula that starts to kill fleas within 24 hours.
  • BREAK THE FLEA CYCLE: Unlike other flea and tick treatments that may temporarily suppress flea activity, PETARMOR Plus Cat Flea Treatment works by effectively breaking the flea life cycle. Kill flea eggs and larvae to prevent re-infestation.
  • FLEA AND TICK PROTECTION: PetArmor Plus for Cats flea drops protects your furry family members from brown dog ticks, American dog ticks, Lone Star ticks, and deer ticks (which may transmit Lyme disease).
  • EASY-TO-USE, LONG-LASTING: PetArmor Plus flea and tick treatment comes with six (6) waterproof topical applications that provide your pet flea protection and control for (6) months
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#5
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PetArmor CAPACTION (nitenpyram) Oral Flea Treatment for Cats, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Cats 2-25 lbs, 6 Doses

Brand: PetArmor
$26.94 ($4.49 / Coun
⭐ 4.2
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    FAST-ACTING: One oral flea tablet starts killing fleas within 30 minutes of administration.
  • SAFE TO USE: This oral flea medication is safe for kittens and cats from 2-25 lbs. 4 weeks and older, when used as directed.
  • TREAT RE-INFESTATIONS FAST: If your pet gets re-invested with fleas simply apply another dose as often as once a day. CapAction Flea Pills are even safe for use on pregnant or breeding cats.
  • EASY TO USE: Without the mess and rubbing off of a flea and tick topical treatment and without the need of a veterinarian prescription this cat flea tablet is administered orally to kill adult fleas fast.
  • KILL FLEAS EFFICIENTLY: CapAction flea treatment has 6 doses and kills adult fleas that may cause allergy dermatitis.
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#6
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CAPSTAR (nitenpyram) Oral Flea Treatment for Cats, Fast Acting Tablets Start Killing Fleas in 30 Minutes, Cats 2-25 lbs, 6 Doses

Brand: Capstar
$29.99 ($5.00 / Coun
⭐ 4.4
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    CAPSTAR (nitenpyram) starts killing adult fleas in just 30 minutes
  • With one dose of CAPSTAR, you can watch the dead fleas fall off your pet
  • If your pet gets reinfested with fleas, simply give another dose as often as once a day
  • CAPSTAR is a fast, effective cat flea treatment that is available over the counter
  • CAPSTAR Oral Flea Treatment for Cats (11.4 mg) is safe for cats and kittens 4 weeks and older that weigh 2-25 pounds
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#7
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Amazon Basics Topical Flea Treatment for Large Cats (Over 9 Pounds), 6 Count (Previously Solimo

Brand: Amazon Basics
$29.99 ($5.00 / Coun
⭐ 4.7
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    FAST-ACTING FLEA MEDICATION FOR CATS: Eliminates fleas in just 12 hours, providing your large cat with swift relief from discomfort with our effective flea medication for cats
  • LONG-LASTING FLEA PREVENTION FOR CATS: Protect your cat from infestations for up to 4 weeks with each application of this flea remover, providing continuous and reliable flea prevention for cats
  • TOPICAL CAT FLEA DROPS FOR REINFESTATION: This cat flea medicine proactively kills reinfesting fleas within 2 hours, efficiently halting the flea lifecycle
  • SUITABLE CAT FLEA MEDS FOR LARGE CATS: Specifically formulated for cats weighing over 9 pounds, offering targeted flea control with our dedicated cat flea meds for your furry companion
  • NON-EXPIRING FLEA KILLER FOR CATS: Enjoy convenience with this flea medicine for cats that maintains its effectiveness over time, without the worry of expiration dates or decreased performance
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#8
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Advantage II Large Cat Vet-Recommended Flea Treatment & Prevention | Cats Over 9 lbs. | 4-Month Supply

Brand: Advantage
No Price
⭐ 4.1
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    Advantage II Large Cat is a leading brand in cat flea treatment and prevention for large cats over 9 lbs., at least 8 weeks of age
  • Vet-recommended, easy-to-apply monthly topical treatment – no hard-to-swallow pills, no prescription needed
  • Delivers total flea protection – kills adult fleas, flea larvae and flea eggs through contact
  • Same-day effectiveness – kills fleas within 12 hours of application and keeps working for 30 days
  • Fragrance-free formula, waterproof after 24 hours of application
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#9
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Amazon Basics Flea and Tick Topical Treatment for Cats (Over 1.5 Pounds), 6 Count (Previously Solimo)

Brand: Amazon Basics
$21.59 ($3.60 / Coun
⭐ 5
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    Same product, new look―This product is identical in manufacturing and formulation as the Solimo brand
  • One 6 dose pack of Amazon Basics Flea & Tick Treatment for Cats (over 1.5 lbs)
  • Amazon Basics Flea & Tick starts eliminating fleas and ticks within 24 hours of treatment
  • Active ingredients (list ingredients) prevent flea infestations by killing flea eggs, flea larvae, mosquitos, biting flies and chewing lice
  • One application provides up to 30 days of protection
  • Waterproof: 24 hours after application your pet’s treatment is protected against rain and water activities
  • Packaging received may vary: you may receive product in Solimo or Amazon Basics Packaging.
  • Amazon Basics Flea and Tick Topical does not expire
  • Satisfaction Guarantee: We’re proud of our products. If you aren’t satisfied, we’ll refund you for any reason within a year of purchase. 1-877-485-0385
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#10
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Frontline Plus Flea and Tick Treatment for Cats Over 1.5 lbs. 3 Treatments

Brand: Frontline
$39.98 ($783.92 / Fl
⭐ 4.1
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    FRONTLINE Plus for Cats provides waterproof, fast-acting, long-lasting flea and tick protection that's proven to kill fleas, flea eggs, flea larvae, chewing lice, and ticks that can transmit Lyme disease
  • Break the flea life cycle with FRONTLINE Plus for Cats, specially formulated with fipronil and (S)-methoprene to kill existing adult fleas, flea eggs and flea larvae to guard against further infestations for flea & tick control
  • Trusted by pet owners for over 20 years, FRONTLINE Plus for Cats can be used on kittens as young as eight weeks old, weighing 1.5 pounds or more; One monthly dose provides protection from fleas & ticks for a full 30 days
  • Even indoor dogs need flea and tick control because you or other pets in the household may bring fleas into the home; These fleas can lead to a flea infestation
  • FRONTLINE Plus also comes in a formula designed for dogs and puppies, 8 weeks and older, weighing 5 lbs and over, providing the same reliable flea & tick protection
  • Treat cats and dogs in the home monthly to effectively control fleas and ticks and prevent the establishment of new infestations
  • Subscribe & save today to make it easier to keep your cat or dog protected year-round and make sure you never run out of FRONTLINE Plus
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