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Updated: 18 Jul 2025

Top 10 High Efficiency Laundry Detergents

#1
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Gain Odor Defense Liquid Laundry Detergent, Super Fresh Blast Scent, 194 fl oz, 134 loads, 2 in 1, Laundry Detergent Liquid Soap, HE compatible

Brand: Gain
$19.94 ($0.15 / load
⭐ 4.4
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    LOOONG-LASTING: Gain Odor Defense Liquid Laundry Detergent Super Fresh Blast Scent capsules break for scent that continues to release during regular wear for lasting freshness for up to 6 weeks from wash until wear
  • ODOR FIGHTING: Bye-bye, stink! Gain Odor Defense Liquid Laundry Detergent lifts away tough in-wear odors at the source, instead of just masking them. So you get the funk out of your clothes, leaving only the delightful scent of nature
  • DESIGNED FOR COLDWATER: Gain Odor Defense Liquid Laundry Detergent delivers a powerful clean, even in cold water
  • HE COMPATIBLE: Safe for use with regular washer and high-efficiency washers, even in cold water!
  • PAIRS WELL WITH: Experience a scent explosion when you use with Gain Scent Booster, Gain Fabric Softener, and Gain Sheets
  • Includes 194 fl oz of Gain Odor Defense Liquid Laundry Detergent, Super Fresh Blast Scent, enough for 134 loads
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#2
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Persil Advanced Clean Oxi+Odor Power, Liquid Laundry Detergent, High Efficiency (HE), Deep Stain Removal, 2X Concentrated, 82.5 fl oz, 82 Loads

Brand: Persil
$23.54 ($0.29 / load
⭐ 4.6
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    With powerful Persil liquid laundry detergent, get a premium deep clean with every wash
  • Persil Advanced Clean Oxi+Odor Power contains powerful stain fighting enzymes and odor eliminating technology
  • Persil Advanced Clean Oxi+Odor Power laundry detergent has fabric protection technology to keep whites and colors vibrant
  • Persil laundry detergent protects fabrics, deep cleans, and helps keep clothes looking newer, longer* *vs leading value detergent
  • This 2X concentrated formula delivers more cleaning power in every drop vs our standard detergent so you don’t have to use as much to get a premium deep clean
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#3
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Gain + Aroma Boost Laundry Detergent Liquid, Original Scent, 107 Loads, 154 fl oz, HE Compatible Laundry Soap with Febreze and Oxi, Gain Laundry Detergent, Liquid Laundry Detergent

Brand: Gain
$15.94 ($0.15 / Load
⭐ 4.7
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    LONG-LASTING SCENT: Gain + Aroma Boost liquid laundry detergent helps lift away dirt and locks in an amazing scent to keep your laundry smelling excellent even after six weeks. From wash until wear, experience the difference of Gain laundry detergent
  • UNIQUE SCENT: Gain laundry detergent has a unique original scent. This liquid laundry detergent can be used in your laundry routine
  • GREAT CLEANING POWER: Gain laundry detergent liquid has great cleaning power
  • MACHINE COMPATIBILITY: This laundry detergent liquid can be used in all washing machines even in cold water
  • LARGE QUANTITY: Includes one 154 fl oz bottle of Gain + Aroma Boost laundry detergent liquid, original scent enough for 107 loads
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#4
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Tide Simply Liquid Laundry Detergent, Refreshing Breeze, 168 oz, 128 Loads, Tide Liquid Laundry Detergent, Laundry Soap

Brand: Tide
$13.94 ($0.11 / Load
⭐ 5
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    TOUGH ON STAINS AND ODORS: Tide Simply Liquid Laundry Detergent is not only easy on your wallet but also tough on stains and odors, providing a cost-effective laundry solution
  • TACKLES COMMON STAINS & ODORS: Tide Simply Liquid Laundry Detergent is an all-in-one detergent that helps tackle 99% of common stains & odors, making it a versatile choice for your laundry needs
  • CRISP REFRESHING BREEZE SCENT: Tide Simply Liquid Laundry Detergent helps leave your clothes smelling fresh and clean after every load, enhancing your laundry experience
  • FLEXIBLE USAGE: This detergent is suitable for all washing machines, offering flexibility in your laundry routine
  • COST-EFFECTIVE: Use Tide Simply liquid laundry detergent for a cost-effective laundry solution, ensuring clean and fresh clothes every time
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#5
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MRS. MEYER'S CLEAN DAY Liquid Laundry Detergent, Biodegradable Formula Infused with Essential Oils, Lavender, 64 oz (64 Loads)

Brand: MRS. MEYER'S CLEAN DAY
$20.97 ($0.33 / load
⭐ 4.7
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    Concentrated detergent formula is effective yet gentle on clothes
  • Contains plant-derived cleaning agents with dirt, stain-fighting enzymes, and other thoughtfully chosen ingredients
  • 64 loads of laundry per bottle
  • Biodegradable formula, HE laundry detergent for use in high efficiency and conventional washing machines
  • Garden-inspired Lavender scented laundry soap with an original and clean floral fragrance
  • Mrs. Meyer's products are made with cruelty-free formulas and are Leaping Bunny certified
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#6
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Persil Original Everyday Clean, Liquid Laundry Detergent, High Efficiency (HE), Deep Stain Removal, 2X Concentrated, 82.5 fl oz, 110 Loads

Brand: Persil
$17.99 ($0.16 / load
⭐ 4.6
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    With powerful Persil liquid laundry detergent, get a premium deep clean with every wash
  • Persil Original laundry detergent has fabric care ingredients to help prevent color fading
  • Persil Original laundry detergent has fabric protection technology to keep whites and colors vibrant
  • Persil laundry detergent protects fabrics, deep cleans, and helps keep clothes looking newer, longer vs leading value detergent
  • This 2X concentrated formula delivers more cleaning power in every drop vs our standard detergent so you don’t have to use as much to get a premium deep clean.
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#7
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ARM & HAMMER Plus OxiClean Odor Blasters Fresh Burst, 128 Loads Liquid Laundry Detergent, 166.5 Fl oz

Brand: Arm & Hammer
$13.98 ($0.11 / Load
⭐ 4.8
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    One 166.5 fl oz bottle of ARM & HAMMER Plus OxiClean with Odor Blasters Laundry Detergent, Fresh Burst Liquid Laundry Detergent cleans 128 medium loads when used as directed
  • Triple-power HE laundry detergent fights tough odors, blasts away stains and boosts freshness so your clothes look and smell their best
  • With trusted ARM & HAMMER Baking Soda plus an odor fighter, this HE laundry detergent is formulated to deeply clean clothes and deliver lasting freshness
  • Laundry stain remover forces out stubborn stains and nasty odors using OxiClean Stain Fighters to remove stains like food, grass, grease and more
  • Odor Blasters fights tough smells like body odor, sweat and musty towels and leave clothes with a lasting Fresh Burst scent
  • Clean Deep, Don’t Spend Deep
  • ARM & HAMMER Baking Soda has been the standard of purity and a trusted household staple in millions of cabinets and pantries for generations of families
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#8
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Gain + Odor Defense Liquid Laundry Detergent Super Fresh Blast Scent, HE Compatible, 107 Loads 154 fl oz, Gain Laundry Detergent, Liquid Laundry Detergent

Brand: Gain
$15.94 ($0.15 / Load
⭐ 5
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    SCENT-SATIONAL ADVENTURE: Take your nose on a scent-sational adventure with Gain laundry detergent
  • 3-IN-1 DETERGENT: Our laundry detergent liquid helps eliminate tough odors in-wear while giving your clothes a powerful clean and lasting freshness.
  • PERFECT MATCH: This liquid laundry detergent matches perfectly with other Gain Plus Odor Defense products for one amazing scent
  • UNIVERSAL USE: Works in all machines and water temperatures, making it a versatile washing detergent
  • SAFE FOR ALL FABRICS: This laundry soap is safe to use on all fabric types. Keep out of reach of children
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#9
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Tide Ultra Oxi Laundry Detergent Liquid Soap, High Efficiency (He), 59 Loads, 84 Fl Oz (Packaging May Vary)

Brand: Tide
$27.85 ($0.47 / load
⭐ 4.6
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    STAIN REMOVAL: Tide Ultra OXI Liquid Laundry Detergent helps remove stains with built-in pre-treaters
  • CONCENTRATED FORMULA: Tide Ultra OXI Liquid Laundry Detergent is a concentrated formula with more cleaning agents and less water in every drop compared to our previous formula
  • ODOR REMOVAL: Tide Ultra OXI Liquid Laundry Detergent helps remove odors left in clothes and active wear
  • TRUSTED BRAND: Tide Ultra OXI Liquid Laundry Detergent is from America's trusted detergent brand
  • HIGH EFFICIENCY COMPATIBLE: Tide Ultra OXI Liquid Laundry Detergent is compatible with both top load and front load High Efficiency (HE) machines
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#10
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Tide Liquid Laundry Detergent, Original, 64 loads, 84 fl oz, HE Compatible (Packaging May Vary)

Brand: Tide
$12.99 ($0.20 / load
⭐ 4.1
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    AMERICA'S DETERGENT: Tide liquid laundry detergent is a popular detergent brand in America, providing a deep clean and a fresh smell
  • DEEP CLEAN: This liquid laundry detergent helps clean deep and leaves a fresh scent, making your laundry smell as good as it looks
  • MULTIPLE BENEFITS: Tide detergent liquid not only helps clean and freshen but also helps whiten and brighten your clothes
  • EASY TO USE: Measure with cap. For small loads, fill just below bar 1. For medium loads, fill just below bar 3. For large loads, fill to bar 5. Add clothes, pour laundry soap into dispenser, start washer
  • ORIGINAL SCENT: Infuse your clothes with the original scent you love, this Tide liquid laundry detergent leaves your clothes smelling fresh and clean
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